LRP8 and Hepatic fibrosis: Similarly, in a mouse model of carbon tetrachloride (CCl4)-induced liver fibrosis (Fig.3), miR-130/301 was increased (Fig. 3A,B) and Pparγ and Lrp8 were correspondingly decreased (Fig.S2), accompanied by a positive correlation among collagen crosslinking, miR-130a expression, and YAP nuclear localization (Fig. 3C).