To determine the effects of the LXR agonist GW3965 (Sigma-Aldrich) and consequent APOE induction on lung fibrosis, as previously described13, mice were exposed to bleomycin (as described above) and simultaneously assigned to control chow or chow supplemented with GW3965 (Research Diets, Inc.)at doses of 100 mg of drug per kilogram of mouse per day (based on average daily intake of 3.5 gm of chow). This evidence concerns the gene APOE and pulmonary fibrosis.