Furthermore, consistent with the direct down-regulation of the associated factors peroxisome proliferator-activated receptor gamma (PPARγ), apolipoprotein E (APOE) and the apolipoprotein E receptor LRP8 by miR-130/301 in PH 9, both Pparγ and Lrp8 were decreased in pulmonary fibrosis (Fig.S1). Here, APOE is linked to pulmonary fibrosis.