Reactivity to D2R was described using ELISA and western blot with antibodies purified from individuals with basal ganglia disorders associated with streptococcal infection, including Sydenham’s chorea and paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), and as such the psychiatric associations encompassed anxiety, obsessions, compulsions and tics (Brimberg et al. 2012). Here, DRD2 is linked to streptococcal infection.