The levels of AcSTAT3 detected in lung (Fig. 7b) and head and neck (Fig. 7c) was consistently opposite to SHP-1 expression, which establishes a strong inverse correlation between STAT3-K685 acetylation and SHP-1 expression (r2=−0.87 for head and neck; r2=−0.55 for lung carcinomas; Fig. 7d). This evidence concerns the gene PTPN6 and lung carcinoma.