PTPN6 and carcinoma: Accordingly, SHP-1 was undetectable in CAF from multiple carcinoma origins compared with three primary hDF (Supplementary Fig. 4i) and regions 1 and 2 of PTPN6 promoter 1 of human CAF were hypermethylated compared with the hDF PTPN6 promoter (Supplementary Fig. 4j).