By analyzing the expression of CCR7 and MUC1 in 153 ESCC tissue samples, we found the co-expression of CCR7 and MUC1 in ESCC, and the two molecules were both correlated with lymph node metastasis and prognosis; furthermore, the patients who co-expressed CCR7 and MUC1 had the highest recurrence rate and the lowest survival rate compared with the rest of the groups. This evidence concerns the gene CCR7 and esophageal squamous cell carcinoma.