Though MUC1 is a heterodimer protein localized on the cellular membrane, many fundamental works have confirmed the constant accumulation of MUC1-C in the cytoplasm, nuclei and mitochondria of cancer cells due to the MUC1-autocleavage [15] and further revealed its role in promoting metastasis by inducing epithelial mesenchymal transition (EMT), promoting cell motility, and up-regulating MMPs and uPA [32–35]. This evidence concerns the gene MUC1 and cancer.