The aberrant overexpression of MUC1 has been detected in ESCC and is correlated with lymphatic metastasis and poor prognosis [17, 30]; Qing Y et al. further confirmed that MUC1-C could promote lymph node metastasis in ESCC by up-regulating the expression of MMP13 [31]. This evidence concerns the gene MMP13 and esophageal squamous cell carcinoma.