The results of mediation analysis were similar when we included the mean methylation of a group of ten AHRR (cg05575921, cg03991871, cg12806681, cg23916896, cg01899089, cg26703534, cg14817490, cg25648203, cg21161138 and cg24090911) and two F2RL3 probes (cg03636183 and cg04259305) located in the body of the gene and significantly associated with lung cancer after false discovery rate correction (data not shown). The gene discussed is AHRR; the disease is lung cancer.