This suggestion is in accordance with an earlier work with the same melanoma lines showing that treatment of tumor-bearing mice with neutralizing antibody against VEGF-A or IL-8 decreased the microvascular density and the growth rate of the primary tumor and reduced the incidence of spontaneous metastases, including lymph node, pulmonary, hepatic, and brain metastases [26]. Here, CXCL8 is linked to neoplasm.