MAPT and Alzheimer disease: Nuclear medicine imaging of the human brain afflicted by Alzheimer’s Disease (AD) has progressed over the last decades from non-specific markers of neurodegeneration, such as altered metabolism [1, 2], blood flow [3], and inflammation [4, 5], to disease-specific markers of amyloid-β [6] and tau tangles [7] believed to instigate the pathologic cascade.