In addition, to extend upon our in vivo study which was conducted in a non-orthologous model of ARPKD, we used WT9-7 and WT9-12 cells, which possess mutated PKD1 allele/s and truncated polycystin-1 protein, to model cellular function in ADPKD. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.