PROK2 and neoplasm: As an unregulated tumor-angiogenesis is known to increase the interstitial fluid pressure and reduces the chemosensitivity of human malignancies including uterine cervical cancer14, 15, we next investigated the role of the MDSC in the expression of Bv8, a potent pro-angiogenic factor that stimulates the proliferation, survival, and migration of endothelial cells16.