Although the blockade of angiopoietin/Tie2 signaling has previously be shown to prevent the recruitment of CD11b+ myeloid cells in a model of airway inflammation (Tabruyn et al, 2010) and in colon cancer (Huang et al, 2011), this study extends these observations to a mouse model of brain cancer. The gene discussed is TEK; the disease is malignant colon neoplasm.