PLA2G7 and periodontitis: In this context, lipoprotein associated phospholipase A2 (Lp- PLA2), an enzyme that has been shown to be a risk factor for cardiovascular disease (CVD) and is believed to be an independent CVD risk factor that is also involved in degradation of the phospholipid mediator platelet-activating factor (PAF) [11–13] was significantly reduced by treatment of periodontitis [9, 14].