Therefore, this study was designed not only to investigate the expression of OATP1B2 and ABCC2 in the liver and hepatoma tissues of an orthotopic transplantation liver cancer rat model which was pretreated with food restriction and diarrhea (FRD-LC), but also to investigate the influential role of JPJD in the expression of OATP1B2 and ABCC2. Here, ABCC2 is linked to liver cancer.