Thus, the increased expression of ABCC2 and decreased expression of OATP1B2 in liver tissues and the decreased expression of ABCC2 and increased expression of OATP1B2 in cancer tissues caused by the administration of 37.50 g·kg−1 JPJD may be mechanisms by which JPJD treats liver cancer with food restriction and diarrhea. This evidence concerns the gene ABCC2 and cancer.