Our data confirm and extend an earlier study illustrating the beneficial effects of autologous HSC gene therapy in BERK SCD mice after sublethal irradiation to facilitate mixed chimerism.27 In that report, lineage negative, c-kit+, Sca-1+ (LSK) BM cells were transduced with lentivirus particles encoding an erythroid specific β-γ-globin hybrid transgene. The gene discussed is KIT; the disease is Schnyder corneal dystrophy.