MAPT and Alzheimer disease: The two major biochemical features related to the neuropathogenesis of AD are the neurofibrillary tangles containing phosphorylated tau protein in soluble intermediate form leading to synaptic toxicity (lack of definitive therapeutic intervention further leads to neurodegeneration) and senile plaques containing amyloid-β-peptide (Aβ) which is a soluble intermediate and inherently deleterious to synapses [8].