We therefore undertook a study to seek a thiol-disulfideoxidoreductase with mHTT lowering effects in HD cells that we could test in HD mice.We found that thioredoxin 1 (TRX1) and thioredoxin-related transmembrane protein 3(TMX3) both decreased levels of mHTT in cells but did not find evidence for a directinteraction with mHTT. Here, TMX3 is linked to Huntington disease.