CD4 and glycogen storage disease VI: The fact that mRNA abundance of nearly all genes studied was reduced in CD4+CD25− T cells from cows with subclinical disease as compared to healthy controls, combined with the significant increases in various responses to MAP-infected MDMs as compared to nil-infected MDMs in these same animals, suggests that cells from cows with subclinical disease, while still responsive to MAP antigens, are substantially less active than T cells from healthy control cows.