EP300 and cancer: For instance, (1) in several human cancer cell lines phosphorylated Y705 and acetylated K685 STAT3 was implicated in the processing of NF-κB p100, which has pro-apoptotic and anti-oncogenic function, to the anti-apoptotic and oncogenic protein p52 (117); and (2) the enhanced nuclear NF-κB p65 levels that are frequently observed in cancer cells was attributed to p65 acetylation brought about by the binding of p65 to activated STAT3 in association with p300 (118).