STAT3 and ischemia: In fact, evidence derived from MLS-STAT3E mitochondria places the contribution of STAT3 to complex I activity downstream of the FMN moiety and in the vicinity of the N2/ubiquinone site, as there is a lack of ischemia-induced ROS in MLS–STAT3E mitochondria whereas NADH-ferricyanide reductase activity is unaffected (88).