While chronic inflammation can lead to amyloidosis, studies have also shown that the NLRP3 inflammasome can be activated in response to different types of amyloid, including amyloid-beta, islet amyloid polypeptide, serum amyloid A, prions, and curli fibers, a type of amyloid found in the biofilm of Escherichia coli and Salmonella enterica serovar Typhimurium (81–86). The gene discussed is NLRP3; the disease is amyloidosis.