In the heart, the cardio-protective effect of HSP90, HSP70, TRiC, as well as a host of small HSPs [αBCrystallin (aka HSPB5), HSP20 (aka HSPB6), HSP22 (aka HSPB8, H11 kinase, and αCCrystallin), HSP27 (aka HSPB1 and HSPB2), and HSP60], has been described in the context of cardiac hypertrophy, heart failure, and ischemia reperfusion disease (34). The gene discussed is HSPB1; the disease is heart failure.