In a multivariable Cox regression model for total death within 2 years, the HR for BNP in the highest quartile (Q4) as compared to the lowest (Q1) was 2.84 (95% CI, 1.13–7.17), p = 0.027 (Table 3), in addition to age [HR 1.05 (95% CI, 1.02–1.08)], p < 0.001 and hypercholesterolemia [HR 0.55 (95% CI, 0.31–0.98)], p = 0.043. This evidence concerns the gene NPPB and familial hypercholesterolemia.