Constitutively active Gαq, Gαq/12, and Gαq/13 overexpressed in human astrocytoma cells increased agonist-activated thromboxane A2 receptor-mediated IL-6 production while mutated Gαq and Gαq/13 overexpression blocks IL-6 production (82). The gene discussed is IL6; the disease is astrocytoma (excluding glioblastoma).