As examples MET+ SU+ GLP-1-RA or MET+ SU+ SGLT2-i may be a good choice for patients that require weight loss and MET+ SU+ GLP-1-RA for patients at risk for hypoglycaemia, whereas MET+ SU+ insulin may provide good blood glucose control in patients where hypoglycaemia and weight gain is not a concern. Here, INS is linked to Hypoglycemia.