MET+ SU+ TZD, MET+ SU+ DPP-4-i and MET+ SU+ insulin had increased odds ratio of hypoglycaemia (Table 3, Fig. 2C), while MET+ SU+ GLP-1-RA did not significantly increase the odds ratio (1.61; 95% CI [0.90–2.87]), when compared to MET+ SU. This evidence concerns the gene GCG and Hypoglycemia.