The results showed that rs1035798 C/C in RAGE gene were strongly associated with an increased risk of HS, while the Golgb1 rs3732410 polymorphism was associated with a reduced risk of HS in younger group (≤50 years old), and the TNFRSF11B rs2073618 was associated with an increased the risk of the disease in elder group (>50 years old). This evidence concerns the gene TNFRSF11B and histiocytic sarcoma.