For four SNPs in the ≤50 year group, allele frequency of RAGE rs1035798 was 4.5% (T) and 95.5% (C) in HS patients, 13.7% (T) and 86.3% (C) in control; allele frequency of TNFRSF11B rs2073617 was 59.1% (T) and 40.9% (C) in HS patients, 62% (T) and 38% (C) in control; allele frequency of TNFRSF11B rs2073618 was 33.3% (C) and 66.7% (G) in HS patients, 75.5% (G) and 24.5% (C) in controls; allele frequency of Golgb1 rs3732410 was 59.1% (A) and 40.9% (G) in HS patients, 54.1% (A) and 45.9% (G) in controls. The gene discussed is TNFRSF11B; the disease is histiocytic sarcoma.