To investigate the cytoprotective role of EPHA2 in lens epithelial cells and the molecular mechanism underlying the association of EPHA2 mutation with age-related cataract, we generated the lentiviral plasmids encoding wild-type EPHA2, EPHA2E825K, and EPHA2I96F and prepared the high-titers of corresponding lentivirus for infection. Here, EPHA2 is linked to infection.