IGHE and allergic rhinitis: One hundred and thirty-one volunteers were enrolled on the basis of the following inclusion criteria: 18–65 years of age, body mass index in the range of 19–32 kg/m2, established allergic rhinitis to grass pollen for more than 2 years, positive skin prick test to grass pollen and grass pollen-specific IgE (≥0.35 kU/L).