This postulate is substantiated by the large European population based cohort study, MeDALL (Mechanisms of the Development of ALLergy), which showed that eczema, rhinitis and asthma may coexist in the absence of IgE sensitization, and that IgE sensitization was not the dominant causal mechanism of comorbidity for these disorders ([22]). Here, IGHE is linked to Eczematoid dermatitis.