MRC1 and Lynch syndrome: MMR genes associated to Lynch syndrome are the following: MLH1 which is localized on 3p21 chromosome (32% of the cases), MSH2 which is localized on 2p16 chromosome (39% of the cases), MSH6 which is localized on 2p16 chromosome (15% of the cases, with a high risk of endometrial cancer) and PMS2 which is localized on 7p22 chromosome (14% of the cases).