TP53 and brain injury: Li induces astrocyte G2/M cell cycle arrest and DNA synthesis with 1 mM concentration in a time- and dose-dependent manner, through inhibition of MEK-ERK phosphorylation with the activation of p38 MAP kinase in the stabilization of p53 induced by nitric oxide (NO) (40, 41), in an opposite effect on the neuronal induced proliferation (40), in consequence to the protective role of Li on brain injuries, and inhibited the cannabinoid withdrawal; and as a candidate it is potent pharmacotherapy for maintenance of bipolar and cannabis-use disorder patients.