BRCA1 and non-small cell lung carcinoma: Rosell et al. [9] showed that BRCA1 mRNA expression, implicated in transcription-coupled nucleotide excision repair (TC-NER) pathway, was the only independent prognostic variable in chemotherapy-naïve patients with early-stage, resected NSCLC and demonstrated that RRM1 mRNA expression did not show a statistically significant impact on OS.