In addition to NFKBIE promoter alterations, highly focal amplifications of MAP3K1 were identified in three tumours, and two novel melanoma‐related genes were found: CBL and FBXW7. Other mutated genes included NF1, CDKN2A, ERBB2, MAP3K1, EGFR, PTPN11, MET, RAC1, SOS2, NRAS and PIK3CA. Mutations in TP53 and amplification of TERT were also observed. The gene discussed is MAP3K1; the disease is melanoma.