INS and Other metabolic disease: To test the hypothesis that altered plasma levels of insulin, leptin, and adiponectin are causative for EI of metabolic disorders in DIO models (Fullston et al. 2013; Ng et al. 2010, 2014; Wei et al. 2014), we induced such hormonal changes in the absence of obesity and most of its complication in F0 male mice by administration of dexamethasone.