VEGFA and retinal detachment: Finkelstein[2] reported that ischemic ME had a favorable visual prognosis in eyes with BRVO, but other investigators have reported poor visual function in eyes with the macular ischemia.[21] The association of serous retinal detachment with visual prognosis is also controversial although Ohashi et al. have reported that eyes with serous retinal detachment from BRVO had poor visual prognoses.[22] However, there is also no doubt that ME is significantly associated the visual impairment of eyes with BRVO, of which the introduction of anti-VEGF agents has improved the visual prognosis.[5,6,7,8]