GPCRs that have received recent attention in the field of diabetes therapeutics include the incretin receptors (GLP1R, GIPR), GPR119, FFAR1 (GPR40), FFAR4 (GPR120) and the bile acid receptor GPBAR1 (TGR5) (for examples, see [2, 3, 5–7]) (see text box). Here, GLP1R is linked to diabetes mellitus.