AKT1 and Huntington disease: By stimulating cells from the StHdhQ111 immortalised embryonic striatal cell model of HD, which carries 111 CAG repeats [44], with epidermal growth factor (EGF), we have created a dynamic model that demonstrates that both AKT and MEK signalling pathways may contribute to the regulation of huntingtin subcellular localisation, as well as to the control of gene expression.