However, as MEK1 phosphorylation was suppressed in StHdhQ111/111 cells, and both AKT1 and MEK1 inhibition are able to alter huntingtin localisation in a similar manner, it is possible that a synergistic mechanism between multiple dysregulated pathways contributes to aberrant transcriptional control and huntingtin mislocalisation in models of HD. This evidence concerns the gene MAP2K1 and Huntington disease.