By stimulating cells from the StHdhQ111 immortalised embryonic striatal cell model of HD, which carries 111 CAG repeats [44], with epidermal growth factor (EGF), we have created a dynamic model that demonstrates that both AKT and MEK signalling pathways may contribute to the regulation of huntingtin subcellular localisation, as well as to the control of gene expression. The gene discussed is HTT; the disease is Huntington disease.