On histological analysis, hearts (ventricle) from both MURC and MURC-Hsp70 Tg mice displayed significant cardiac fibrosis (Fig 4A) and this was accompanied with increased profibrotic gene expression including collagen 1, collagen 3 and connective tissue growth factor (Ctgf) in the ventricle (Fig 4B). Here, CCN2 is linked to fibrosis.