Dysregulated neuronal Ca2+ homeostasis is associated with cellular processes in AD (Bezprozvanny and Mattson, 2008); thus, DSCR1 and its target calcineurin have been implicated in a variety of events that occur in the brains of individuals with AD (Ermak and Davies, 2003; Reese and Taglialatela, 2010; Ermak et al., 2011; Reese et al., 2011). The gene discussed is RCAN1; the disease is Alzheimer disease.