Because DSCR1 levels are increased in the brains of individuals with AD (Ermak et al., 2001), we investigated whether sra is similarly upregulated in Drosophila brain by ectopically expressing human Aβ42. The sra expression levels in fly head regions pan-neuronally expressing human Aβ42 was measured by real-time quantitative PCR and compared with that of a control. Here, RCAN1 is linked to Alzheimer disease.