DSCR1 mRNA and protein levels are increased in the brains of individuals with AD (Ermak et al., 2001; Harris et al., 2007), and DSCR1 is associated with neuronal cell death (Sun et al., 2011, , 2014; Kim et al., 2013; Wu and Song, 2013). This evidence concerns the gene RCAN1 and Alzheimer disease.