Transplantation of neurospheres into nude mice replicates many features of human glioblastomas, such as histopathology (pseudopalisades and necrosis), cellular characteristics (differentiation and invasion) and chromosomal aberrations typical of patient tumors (EGFR activation and telomerase re-activation) compared with the serum-grown U87 counterparts, which show none of these characteristics (Molina et al., 2014). This evidence concerns the gene EGFR and glioblastoma.