MiR-21 blocked pancreatic β-cell death [28] and miR-183 suppressed apoptosis in esophageal cancer cells [29] by targeting PDCD4. Currently, whether PDCD4 can be controlled by cardiac-abundant miR-499 in LPS-stimulated cardiomyocyte apoptosis is unclear. The gene discussed is PDCD4; the disease is esophageal cancer.