AKT1 and myocardial infarction: Early insulin treatment also improved subsequent insulin-stimulated myocardial FDG uptake and Akt phosphorylation 1 wk post-MI (Fig. 5A,C,D), and alleviated cardiac dysfunction and dilation 4 wk post-MI as evidenced by increased EF (Fig. 5E) and decreased LVESD (Fig. 5F).