RBFOX1 and autism: Additionally, HNRNPH1 and RBFOX1/2 coordinate splicing [56, 57] and knockdown RBFOX1 (an autism-associated RBP involved in neural development [58]) in human neural progenitor cells revealed over 200 alternatively spliced genes containing HNRNPH1 binding sites [56] and 524 genes containing binding sites for ELAVL2, a neurodevelopmental RBP [59] that was downregulated in Line 4a (Fig 4).