Interestingly, HNRNPH1 binding affinity and splicing can be modulated by genome-wide significant SNPs associated with bipolar disorder, major depressive disorder, and schizophrenia, including rs1006737 (CACNA1C), rs2251219 (PBRM1), and rs1076560 (DRD2) [55]. The gene discussed is PBRM1; the disease is major depressive disorder.