Many studies have demonstrated that CRP level and fractional changes in CRP level may be a useful and important marker to predict initial IVIG resistance in KD patients.[25–27] Moreover, KD is an acute systematic vasculitis which causes hydrops of the gallbladder,[28] and we also previously showed that a higher CRP level is associated with sonographic gallbladder abnormalities[29]. The gene discussed is CRP; the disease is gallbladder disorder.