F2RL1 and asthma: However, the fact that patients that experienced exacerbations over the last year had higher PAR-2 expression on CD14++CD16+ cells and their lung function inversely correlated with PAR-2 expression, indicates that the % CD14++CD16+PAR-2+ may be an important inflammatory biomarker for both severe asthma and for severe asthma with frequent exacerbations.