CNTF and early-onset autosomal dominant Alzheimer disease: This cytokine could be important for the maintenance of control-like rPVT performance in this group, given that administration of CNTF reportedly improves cognitive function and/or motor performance in preclinical models of Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotropic lateral sclerosis (for a review, see [44]).