Recently, further studies with new generation genomic sequencing enlightened the genomic landscape of recurring sporadic PC and depicted multiple somatic mutations in other genes than HRPT2. Some single nucleotide point mutations were located to well-known genes such as MTOR, MLL2 and CDKN2C. Loss of function was found in PIK3CA gene, and truncating mutations were demonstrated in CDKN2C and THRAP3 genes. This evidence concerns the gene THRAP3 and pachyonychia congenita.