In contrast, the knockdown of SUN2 reduced lung cancer cell apoptosis (Fig. 4c,d and Supplementary Fig. S6a).Moreover, the overexpression of SUN2 increased the cleavage of PARP, a well-known marker of cell apoptosis (Fig. 4e).Because SUN2 induces lung cancer cell apoptosis, we sought to explore the association of SUN2 expression with cisplatin sensitivity in vitro. The gene discussed is SUN2; the disease is lung cancer.