The forced expression or deletion of SUN2 increased or decreased, respectively, the sensitivity of lung cancer cells to cisplatin, as shown by the cell viability assay(Fig. 4f,g and Supplementary Fig. S6b).The colony formation assay also indicated that overexpression of SUN2 decreased cell growth and increased the sensitivity of H460 cells to cisplatin (Fig. 4h,i).Taken together, these findings indicated that SUN2 induces lung cancer cell apoptosis and increases their chemotherapy sensitivity. Here, SUN2 is linked to lung carcinoma.