SUN2 and lung carcinoma: In contrast, the knockdown of SUN2 reduced lung cancer cell apoptosis (Fig. 4c,d and Supplementary Fig. S6a).Moreover, the overexpression of SUN2 increased the cleavage of PARP, a well-known marker of cell apoptosis (Fig. 4e).Because SUN2 induces lung cancer cell apoptosis, we sought to explore the association of SUN2 expression with cisplatin sensitivity in vitro.