TRPM7 and acute basophilic leukemia: In addition, TRP currents including TRPV5 and TRPM7 are reduced by intracellular Mg2+ as well as other divalent such as Ba2+, Sr2+, Mn2+, and Zn2+ through charge shielding of PIP2 by cations in rat basophilic leukemia and T-lymphocyte and in heterologous expression systems [9,27,33].