The latter may be induced by aberrant expression of wild-type and/or mutated Gq-GPCRs, as well as constitutively active Gαq/11 mutants such as Gαq/11R183C or Gαq/11Q209L, respectively, both considered as oncogenic drivers in melanomas of the eye and skin40, 41. The gene discussed is GNAQ; the disease is melanoma.