We found FR-sensitive reductions of basal signalling in B16, MZ7 and Hcmel12 but not in Mamel65, Mamel15, Mamel119 or Skmel28 cells (Fig. 8a,b; for mutational status of melanoma cells regarding mutant Gαq/11 alleles and key MAP kinase pathway drivers B-Raf and N-Ras, see Supplementary Table 2). This evidence concerns the gene BRAF and melanoma.