This observation is relevant because IL-6 is a proinflammatory cytokine that plays a relevant role in the pathogenesis of RA, namely in Th17 polarization and plasma B cell differentiation, in the production of chemokines, adhesion molecules, and VEGF, and in the secretion of RANKL and MMPs, amplifying inflammatory cell infiltration and inducing osteoclastogenesis [59–61]. The gene discussed is TNFSF11; the disease is rheumatoid arthritis.