Knockdown of FOXA1 and FOXA2 results in increased cell migration in pancreatic cancer respectively41, indicating that both FOXA1 and FOXA2 inhibit transition of the epithelial stage to mesenchymal stage as a tumor suppressor, however, another reports FOXA1 functions a tumor promoter42 and FOXA2 is regarded as a tumor suppressor43, 44. The gene discussed is FOXA2; the disease is familial pancreatic carcinoma.