Fig. 1E showed that FOXA1 increased in lung caner and Fig. 1F demonstrated that FOXA2 decreased in lung cancer. Interestingly, the ratio of FoxA1/FoxA2 increased in lung cancer as compare with normal lung tissues (Fig. 1G). Furthermore, we found that FOXA1 expression level was positively related with HOTAIR level (Fig. 1H). Meanwhile, the expression of FOXA2 and the ratio of FOXA1/FOXA2 were reversely correlated with the expression level of HOTAIR (Fig. 1I,J), indicating that HOTAIR is possibly associated with FOXA1 and FOXA2. The gene discussed is HOTAIR; the disease is lung cancer.