Furthermore, it has been previously demonstrated that epigenetic-targeted therapies, including inhibitors of histone deacetylases (HDACI), retain the ability to mediate cell death in the absence of a functional apoptosome via induction of autophagy.18, 19 One such hallmark of drug-induced autophagy is a conversion of LC3B-I to LC3B-II, which can be detected by western blotting.20, 21 We therefore performed a time course treatment of Eμ-myc/apaf1−/− lymphomas with I-BET762 in vitro and examined LC3B protein level changes. Here, MYC is linked to lymphoma.