LD70 concentrations of I-BET762 were sufficient to induce hallmark features of apoptosis, including loss of mitochondrial membrane potential, caspase activation, loss of clonogenic potential (Eμ-myc lymphomas), increased cell surface exposure of phosphotidylserine and DNA fragmentation (Figures 1a and b, Supplementary Figure S1 and Supplementary Tables S1 and S2). The gene discussed is MYC; the disease is lymphoma.