Exposure of Eμ-myc/Bcl-2 and U2932-4RH lymphomas to ABT-263 LD50 in combination with the respective I-BET762 LD70 concentrations showed significant loss of mitochondrial membrane potential, cell viability and an increase in DNA fragmentation (Figures 4a and b,Supplementary Figure S3b and Supplementary Table S4). The gene discussed is BCL2; the disease is lymphoma.