However, an interaction analysis between classical HLA expression and total CD8+ T cell infiltration in tumor tissue revealed a clear beneficial effect of a dense CD8+ T cell infiltration in HLA-B/C positive tumors (HR 0.212, 95% CI 0.074-0.606, p=0.004) or HLA-A and HLA-B/C-positive tumors (HR 0.215, 95% CI 0.069-0.673, p=0.008) with respect to OS (Table 2 and Figure 3). Here, CD8A is linked to neoplasm.